The Nicomp® DLS and the AccuSizer® SPOS systems are frequently used to measure the size, aggregation, and surface charge (zeta potential) of proteins.

The Nicomp DLS system has the sensitivity to measure monomers, dimers, and trimers at small sizes and at low concentration – including lysozyme at 0.1 mg/mL. The AccuSizer SIS system can be used to measure to measure protein aggregation per the new USP <787> test. The dual sensor AccuSizer FX Nano system is the only optical particle counter capable of measuring protein size and count down to 0.150 µm using only 150 µL of sample.