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AccuSizer® SPOS Systems

A comprehensive portfolio of high accuracy and resolution liquid particle counters that determine particle size and concentration of your suspensions.

Uses single particle optical sizing (SPOS) technology to provide extended dynamic size and concentration ranges
Can be used as a liquid particle counter for contamination applications or as sophisticated particle size analyzer
Highest sensitivity technology available to determine tails of distribution such as large particle counts (LPC) in CMP slurries, protein aggregates, or tails of emulsions (PFAT5)
Fast, multi-channel pulse height analyzers that can report results in up to 1024 size bins
Several fluidics configurations are available to deliver the sample to the sensor directly or with auto dilution to avoid coincidence errors
Reference our Particle Characterization Applications page for additional information

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Interested in AccuSizer® SPOS Systems?

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Applications AccuSizer® SPOS Systems Applications

AccuSizer SPOS Systems are ideal for measuring particle size and concentration in:

Pharmaceutical injectables
Chemical Mechanical Planarization (CMP) slurries
Filter testing
Contamination
Emulsions
Microbubbles
Inks and paints

Specifications

System Features

All systems consist of a sensor, pulse height analyzer (counter), and fluidics to transport the sample through the sensor. Particles flowing through the sensor scatter and obscure the incident laser beam. This light interaction creates pulses that are proportional to the particle size. The counter converts these pulses to particle size.

Sensors:	LE400	Collimated beam, scatter + extinction, 0.5-400 μm
	FX	Focused beam, extinction 0.7-20 μm at high concentration
	FX-Nano	Focused beam, scatter 0.15-10+ μm at high concentration
	LE1000	Extinction, 2-1000 μm
	LE2500	Extinction, 25-2500 μm
Counter:	The counter provides high resolution results in up to 1024 size channels
Fluidics:	The sample can be transported through the sensor either without dilution or with single and two stage autodilution samplers

High Resolution Particle Counters

AccuSizer SIS System

The most advanced liquid particle counter for USP <787>, <788>, and <789> testing
Syringe pump pulls accurate and precise sample volumes as low as 150 µL
Automated analysis using autosampler and microplate reader available
Two sensor LE400 plus FX-Nano system counts and sizes down to 150 nm

AccuSizer AD System

The most popular for general particle size analysis applications
Performs exponential autodilution while providing accurate concentration information

AccuSizer APS System

Uses a unique, two-stage fluidics system that measures particle size and count in high concentration suspensions
Ideal for high concentration ink samples and for USP <729> testing of lipid injectable emulsions

AccuSizer FX-Nano AD System

Uses LE400 plus FX-Nano sensors with AD-style exponential autodilution down to 150 nm
Can analyze high concentration samples up to 10⁶ particles/mL
Ideal for filter testing and high concentration protein samples

Successfully Opted for software Updates

Reference Materials Product Documentation

Published Aug 14, 2020 Data Sheet AccuSizer ® A7000 SIS Liquid Particle Counter/ParticleSize Analyzer

Download PDF 277.6 kB

Published Aug 1, 2020 Data Sheet AccuSizer ® A2000 USP Liquid Particle Counter

Download PDF 292.1 kB

Published Apr 29, 2019 Data Sheet AccuSizer® A2000 MPA Microplate Particle Analyzer

Download PDF 373.1 kB

Published May 6, 2019 Data Sheet AccuSizer® A2000 Oil Contamination Monitor

Download PDF 550.3 kB

Published Aug 12, 2019 Data Sheet AccuSizer ® A2000 CMS Automated Liquid Particle Counter for Hydraulic Fluids and Oils

Download PDF 418.9 kB

Published Jul 23, 2019 Data Sheet AccuSizer ® A9000 FX NANO SIS and AD Particle Count/Size Analyzer

Download PDF 558.5 kB

Published Aug 1, 2020 Data Sheet AccuSizer ® Sensors

Download PDF 569.1 kB

Published Feb 27, 2020 Data Sheet Why Buy an AccuSizer® SPOS System?

Download PDF 597.4 kB

Published Aug 1, 2020 Brochure AccuSizer ® A7000 Single Particle Optical Sizing

Download PDF 1.5 MB

Published Sep 12, 2019 Technical Note Cleaning Methods AccuSizer ® FX Nano

Download PDF 80.0 kB

Published Dec 13, 2019 Technical Note Cleaning Procedure for AccuSizer A2000

Download PDF 75.6 kB

Published Aug 12, 2019 Technical Note AccuSizer ® Data Interpretation

Download PDF 844.5 kB

Published Sep 12, 2019 Technical Note How Many Particles to Measure

Download PDF 172.9 kB

Published Aug 20, 2019 Technical Note Low Volume Particle Size and Count Analysis

Download PDF 108.8 kB

Published Apr 30, 2020 Technical Note AccuSizer® System Version 3.0 Software Testing

Download PDF 1.6 MB

Published Aug 7, 2019 Technical Note SPOS vs. Laser Diffraction

Download PDF 1.1 MB

Published Apr 17, 2020 Technical Note Autodilution AccuSizer® SPOS System

Download PDF 142.9 kB

Published Mar 1, 2021 Application Note Monitoring Particulate Contamination in Medical Devices

Download PDF 760.0 kB

Published May 1, 2020 Technical Note AccuSizer® SPOS System and Nicomp® DLS System

Download PDF 412.8 kB

Published Aug 20, 2019 Application Note Aramus™ Single-Use Bag Particle Testing

Download PDF 561.2 kB

Published Jan 8, 2020 Application Note CMP Slurries

Download PDF 359.0 kB

Published Jul 25, 2019 Application Note CMP Slurry Filter Testing

Download PDF 607.7 kB

Published Aug 14, 2019 Application Note Detecting Tails in CMP Slurries

Download PDF 353.1 kB

Published Jan 6, 2020 Application Note Droplet Size Analysis of Mayonnaise

Download PDF 936.9 kB

Published Nov 20, 2019 Application Note Effect of Silicone Oil Droplets in Pre-Filled Syringes

Download PDF 642.4 kB

Published Sep 13, 2019 Application Note Emulsion Stability

Download PDF 1.2 MB

Published Jan 6, 2020 Application Note Filter Testing

Download PDF 595.7 kB

Published Oct 4, 2019 Application Note ISO 4406 Testing: ContaminationParticles in Oil

Download PDF 592.8 kB

Published May 15, 2020 Application Note Laboratory AccuSizer® Systems for CMP Slurries

Download PDF 2.0 MB

Published Sep 12, 2019 Application Note Liposomes

Download PDF 856.9 kB

Published Jan 27, 2020 Application Note Mean Particle Size and Zeta Potential Analysis of CMP Slurries

Download PDF 1.4 MB

Published Jul 29, 2019 Application Note Microbubbles

Download PDF 290.8 kB

Published Nov 8, 2019 Application Note Particle Size Analysis of Active Pharmaceutical Ingredients (APIs)

Download PDF 1.1 MB

Published Aug 19, 2019 Application Note Particle Size of Inkjet Inks

Download PDF 333.6 kB

Published Sep 12, 2019 Application Note Protein Aggregation

Download PDF 1.6 MB

Published Jul 30, 2019 Application Note Protein Formulation Screening and USP <787> Testing

Download PDF 1.3 MB

Published Oct 4, 2019 Application Note Soft Drink Emulsions

Download PDF 551.6 kB

Published Dec 16, 2019 Application Note Subvisible Particulate Matter Testing

Download PDF 1.0 MB

Published Dec 16, 2019 Application Note Techniques to Measure Size of CMP Slurries

Download PDF 758.0 kB

Published Sep 12, 2019 Application Note USP <729> Globule Size Distribution in Lipid Injectable Emulsions

Download PDF 510.0 kB

Published Jul 25, 2019 Application Note USP <787> Testing Therapeutic Protein Injections

Download PDF 436.3 kB

Published Aug 1, 2020 Application Note USP <788> Particulate Matter in Injections

Download PDF 633.5 kB

Published Aug 1, 2020 Application Note USP <789> Particulate Matter in Ophthalmic Solutions

Download PDF 672.9 kB

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